Subcellular organization of the cAMP signaling pathway
M Zaccolo, A Zerio, MJ Lobo, C Garland - Pharmacological reviews, 2021 - Elsevier
The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling
SE Anton, C Kayser, I Maiellaro, K Nemec, J Möller… - Cell, 2022 - cell.com
G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
G protein–coupled receptor signaling: new insights define cellular nanodomains
G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …
family and are involved in the regulation of most cell functions. Most of them reside …
The intrinsic cardiac nervous system and its role in cardiac pacemaking and conduction
The cardiac autonomic nervous system (CANS) plays a key role for the regulation of cardiac
activity with its dysregulation being involved in various heart diseases, such as cardiac …
activity with its dysregulation being involved in various heart diseases, such as cardiac …
A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging
Abstract cAMP is a key second messenger that regulates diverse cellular functions including
neural plasticity. However, the spatiotemporal dynamics of intracellular cAMP in intact …
neural plasticity. However, the spatiotemporal dynamics of intracellular cAMP in intact …
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms
KF Ostrom, JE LaVigne, TF Brust… - Physiological …, 2022 - journals.physiology.org
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …
Nanodomain cAMP signaling in cardiac pathophysiology: potential for develo** targeted therapeutic interventions
M Zaccolo, D Kovanich - Physiological reviews, 2025 - journals.physiology.org
The 3′, 5′-cyclic adenosine monophosphate (cAMP) mediates the effects of sympathetic
stimulation on the rate and strength of cardiac contraction. Beyond this pivotal role, in …
stimulation on the rate and strength of cardiac contraction. Beyond this pivotal role, in …
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice
Protein kinases control nearly every facet of cellular function. These key signaling nodes
integrate diverse pathway inputs to regulate complex physiological processes, and aberrant …
integrate diverse pathway inputs to regulate complex physiological processes, and aberrant …
Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling
Y Manchanda, L ElEid, AI Oqua, Z Ramchunder… - Science …, 2024 - science.org
Mini-G proteins are engineered, thermostable variants of Gα subunits designed to stabilize
G protein–coupled receptors (GPCRs) in their active conformations. Because of their small …
G protein–coupled receptors (GPCRs) in their active conformations. Because of their small …