Inflammatory aspects of Alzheimer's disease
P Botella Lucena, MT Heneka - Acta Neuropathologica, 2024 - Springer
Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …
disorder. AD is characterized by progressive cognitive decline and memory loss, with …
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease
The integration of quantitative trait loci (QTLs) with disease genome-wide association
studies (GWASs) has proven successful in prioritizing candidate genes at disease …
studies (GWASs) has proven successful in prioritizing candidate genes at disease …
[HTML][HTML] TGF-β Signaling in Microglia: A Key Regulator of Development, Homeostasis and Reactivity
L Li, B Sun, OA Harris, J Luo - Biomedicines, 2024 - mdpi.com
Microglia, the resident immune cells of the central nervous system (CNS), are crucial for
normal brain development and function. They become reactive in response to brain injury …
normal brain development and function. They become reactive in response to brain injury …
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington
University in St. Louis has pioneered and led worldwide seminal studies that have …
University in St. Louis has pioneered and led worldwide seminal studies that have …
Decoding sTREM2: its impact on Alzheimer's disease–a comprehensive review of mechanisms and implications
C Lin, Y Kong, Q Chen, J Zeng, X Pan… - Frontiers in Aging …, 2024 - frontiersin.org
Soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) plays a crucial role in
the pathogenesis of Alzheimer's disease (AD). This review comprehensively examines …
the pathogenesis of Alzheimer's disease (AD). This review comprehensively examines …
Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis
R Wang, Y Zhan, W Zhu, Q Yang, J Pei - Frontiers in Aging …, 2024 - frontiersin.org
Objective Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a potential
neuroinflammatory biomarker linked to the pathogenesis of Alzheimer's disease (AD) and …
neuroinflammatory biomarker linked to the pathogenesis of Alzheimer's disease (AD) and …
[HTML][HTML] Immunological alterations in patients with current and lifetime suicide ideation and attempts: Examining the relationship with depressive symptoms
LN Grendas, EAC Silva, RIÁ Casiani, A Olaviaga… - Brain, Behavior, & …, 2024 - Elsevier
Background Suicidal ideation and attempt (SI/SA) have been associated with dysregulation
of the immune response and inflammation. However, few studies have explored how innate …
of the immune response and inflammation. However, few studies have explored how innate …
[HTML][HTML] Cognitive Decline in Ageing and Disease: Risk factors, Genetics and Treatments
E Colita, VO Mateescu, DG Olaru… - Current Health …, 2024 - pmc.ncbi.nlm.nih.gov
Aging is the primary risk factor for cognitive decline, impacting multiple cognitive domains
and significantly elevating the risk of conditions such as mild cognitive impairment and …
and significantly elevating the risk of conditions such as mild cognitive impairment and …
A genetic and proteomic comparison of key AD biomarkers across tissues
TW Marsh, D Western, J Timsina… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Plasma has been proposed as an alternative to cerebrospinal fluid (CSF)
for measuring Alzheimer's disease (AD) biomarkers, but no studies have analyzed in detail …
for measuring Alzheimer's disease (AD) biomarkers, but no studies have analyzed in detail …
Association between a single‐nucleotide polymorphism of the angiotensin‐converting enzyme gene and susceptibility to systemic lupus erythematosus in the …
Q Zhang, Y Zhuang, X Zhang, G Lin… - International Journal …, 2024 - Wiley Online Library
The angiotensin‐converting enzyme (ACE) gene plays a significant role in regulating
immune responses and inflammatory processes, thus impacting the susceptibility to …
immune responses and inflammatory processes, thus impacting the susceptibility to …