Modifiable risk factors in knee osteoarthritis: treatment implications
Optimal management of knee osteoarthritis (KOA) should include, where possible,
modification of risk factors through targeted interventions. The objectives of the present …
modification of risk factors through targeted interventions. The objectives of the present …
Metformin: a potential therapeutic tool for rheumatologists
Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes, acting via
indirect activation of 5′ Adenosine Monophosphate-activated Protein Kinase (AMPK) …
indirect activation of 5′ Adenosine Monophosphate-activated Protein Kinase (AMPK) …
Association between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative—a prospective cohort …
Objective To examine whether metformin use was associated with knee cartilage volume
loss over 4 years and risk of total knee replacement over 6 years in obese individuals with …
loss over 4 years and risk of total knee replacement over 6 years in obese individuals with …
[HTML][HTML] Metabolic osteoarthritis–relation of diabetes and cardiovascular disease with knee osteoarthritis
L Kuusalo, DT Felson, N Wang, CE Lewis… - Osteoarthritis and …, 2021 - Elsevier
Objective There is an interest in identifying a metabolic OA phenotype. We therefore
assessed the relation of diabetes and cardiovascular disease to prevalent and incident …
assessed the relation of diabetes and cardiovascular disease to prevalent and incident …
Association of metabolic syndrome with knee and hand osteoarthritis: a community-based study of women
MT Sanchez-Santos, A Judge, M Gulati… - Seminars in arthritis and …, 2019 - Elsevier
Objective It is unclear whether the association between osteoarthritis (OA) and metabolic
syndrome (MetS) varies with the site of the affected joint and the presence of pain. Our aim …
syndrome (MetS) varies with the site of the affected joint and the presence of pain. Our aim …
Osteoarthritis and diabetes: Where are we and where should we go?
Diabetes mellitus (DM) and osteoarthritis (OA) are chronic noncommunicable diseases that
affect millions of people worldwide. OA and DM are prevalent worldwide and associated …
affect millions of people worldwide. OA and DM are prevalent worldwide and associated …
Diabetes mellitus is not a risk factor for osteoarthritis
Background Association between diabetes mellitus (DM) and risk of osteoarthritis (OA) can
be confounded by body mass index (BMI), a strong risk factor for both conditions. We …
be confounded by body mass index (BMI), a strong risk factor for both conditions. We …
The prevalence of type 2 diabetes and associated risk factors with generalized osteoarthritis: a retrospective study using ICD codes for clinical data repository system
Objective Type 2 diabetes mellitus (T2DM) has been associated with osteoarthritis (OA).
T2DM may be associated with generalized OA (GOA≥ 3 joints) rather than localized OA …
T2DM may be associated with generalized OA (GOA≥ 3 joints) rather than localized OA …
Setting up distinctive outcome measures for each osteoarthritis phenotype
JA Roman-Blas, LA Mendoza-Torres… - Therapeutic …, 2020 - journals.sagepub.com
Osteoarthritis (OA) is an evolving chronic joint disease with a huge global impact. Given the
intricate nature of the etiopathogenesis and subsequent high heterogeneity in the clinical …
intricate nature of the etiopathogenesis and subsequent high heterogeneity in the clinical …
Association between metabolic syndrome and knee structural change on MRI
Objective To examine the association of metabolic syndrome (MetS) and its components
with knee cartilage volume loss and bone marrow lesion (BML) change. Methods …
with knee cartilage volume loss and bone marrow lesion (BML) change. Methods …