Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has
been highlighted for its role in early-onset Parkinson's disease. In recent years, an …

Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial
biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health …

Mitochondria are known as highly dynamic organelles essential for energy production.
Intriguingly, in the recent years, mitochondria have revealed the ability to maintain cell …

Colorectal carcinoma (CRC) is a common cause of cancer-related death worldwide. Indeed,
treatment failures are triggered by cancer stem cells (CSCs) that give rise to tumor …

Podocytes are part of the glomerular filtration membrane in kidney and serve to prevent the
filtration of protein from the blood. Several evidences suggest that mitochondrial dysfunction …

Obesity exacerbates tissue degeneration and compromises the integrity and reparative
potential of mesenchymal stem/stromal cells (MSCs), but the underlying mechanisms have …

Transplantation of autologous mesenchymal stem cells (MSCs) may be a viable option for
treatment of several diseases. MSCs efficacy depends on adequate function of their …

Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the HSP90
family, controls a variety of physiological functions, including cell proliferation, differentiation …

Autologous mesenchymal stem/stromal cells (MSCs) have demonstrated important
therapeutic effects in several diseases. Cardiovascular risk factors may impair MSC …