In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Regulatory signals provide negative input to immunological networks promoting resolution
of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily …

Myocardial ischemia reperfusion syndrome is a complex entity where many inflammatory
mediators play different roles, both to enhance myocardial infarction‐derived damage and to …

Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal
aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a β-galactoside …

During myocardial infarction, sterile inflammation occurs. The danger model is a solid
theoretic framework that explains this inflammation as danger associated molecular patterns …

Galectins are β-galactoside-binding proteins that bind and crosslink molecules via their
sugar moieties, forming signaling and adhesion networks involved in cellular …