Chronic pain affects a substantial portion of the global population, significantly impacting
quality of life and well-being. This condition involves complex mechanisms, including …

The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …

Objectives: To characterize the molecular and cellular pathways contributing to acute and
chronic pain states. Methods: Cross-sectional observational genome-wide association …

Chronic pelvic pain (CPP) in women with no obvious pelvic pathology has few evidence-
based treatment options. Our recent multicenter randomized controlled trial (GaPP2) in …

Inflammation is linked with chronic pain but the extent to which this relationship is associated
with biopsychosocial factors is not known. We investigated relationships between blood C …

Purpose Causal mechanisms underlying systemic inflammation in spinal & widespread pain
remain an intractable experimental challenge. Here we examined whether:(i) associations …

Menstrually-related migraine (MM) is a primary migraine in women of reproductive age. The
underlying neural mechanism of MM was still unclear. In this study, we aimed to reveal the …

Chronic overlap** pain conditions (COPCs) are a subset of chronic pain conditions
commonly comorbid with one another and more prevalent in women and individuals …

Resilience is an important personal characteristic that influences health and recovery.
Previous studies of chronic pain suggest that highly resilient people may be more effective at …

Background Chronic pain is a common, poorly understood condition. Genetic studies
including genome-wide association studies have identified many relevant variants, which …