Role of ErbB4 in breast cancer
M Sundvall, K Il**, S Kilpinen, H Sara… - Journal of mammary …, 2008 - Springer
Members of the ErbB subfamily of receptor tyrosine kinases are important regulators of
normal mammary gland physiology, and aberrations in their signaling have been associated …
normal mammary gland physiology, and aberrations in their signaling have been associated …
Cell and molecular biology of epidermal growth factor receptor
BP Ceresa, JL Peterson - International review of cell and molecular biology, 2014 - Elsevier
The epidermal growth factor receptor (EGFR) has been one of the most intensely studied
cell surface receptors due to its well-established roles in developmental biology, tissue …
cell surface receptors due to its well-established roles in developmental biology, tissue …
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy
Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are implicated in
schizophrenia, but the mediating mechanisms are unknown. Here we identify a genetically …
schizophrenia, but the mediating mechanisms are unknown. Here we identify a genetically …
ERBB4 is over-expressed in human colon cancer and enhances cellular transformation
The ERBB4 receptor tyrosine kinase promotes colonocyte survival. Herein, we tested
whether ERBB4's antiapoptotic signaling promotes transformation and colorectal …
whether ERBB4's antiapoptotic signaling promotes transformation and colorectal …
Comparison of visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer
Background: Immunohistochemistry of Ki-67 protein is widely used to assess tumour
proliferation, and is an established prognostic factor in breast cancer. There is interest in …
proliferation, and is an established prognostic factor in breast cancer. There is interest in …
Association of Wwox with ErbB4 in breast cancer
WWOX, WW domain-containing oxidoreductase, is a tumor suppressor that is altered in
many human cancers, including breast cancer. Wwox interacts with the ErbB4 receptor …
many human cancers, including breast cancer. Wwox interacts with the ErbB4 receptor …
HER4 intracellular domain (4ICD) activity in the develo** mammary gland and breast cancer
FE Jones - Journal of mammary gland biology and neoplasia, 2008 - Springer
The HER4 receptor tyrosine kinase was the final member of the EGFR-family to be
discovered. In contrast to the other three members of this receptor family which function …
discovered. In contrast to the other three members of this receptor family which function …
The relationship between lymphovascular invasion and angiogenesis, hormone receptors, cell proliferation and survival in patients with primary operable invasive …
Background Several well-established tumour prognostic factors are used to guide the
clinical management of patients with breast cancer. Lymphovascular invasion and …
clinical management of patients with breast cancer. Lymphovascular invasion and …
[HTML][HTML] Human epidermal growth factor receptor 4 (HER4) is a favorable prognostic marker of breast cancer: a systematic review and meta-analysis
Based on a large cohort of clinical studies involving a total of 8024 patients and reporting the
effects of HER4 on breast cancer prognosis, we conducted the first meta-analysis and …
effects of HER4 on breast cancer prognosis, we conducted the first meta-analysis and …
The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis
Greater than 40% of breast cancer patients treated with tamoxifen exhibit de novo or
acquired tumor resistance. Recent clinical evidence indicates that loss of expression of …
acquired tumor resistance. Recent clinical evidence indicates that loss of expression of …