The problem of resistance to therapy in cancer is multifaceted. Here we take a reductionist
approach to define and separate the key determinants of drug resistance, which include …

CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

For cancer screening to be successful, it should primarily detect cancers with lethal potential
or their precursors early, leading to therapy that reduces mortality and morbidity. Screening …

High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

Objective To review the trends in and principles of cancer screening and early detection.
Data Sources Journal articles, United States Preventive Services Task Force (USPSTF) …

There are few medical issues that have generated as much controversy as screening for
breast cancer. In science, controversy often stimulates innovation; however, the intensely …

Substantial progress has been made in cancer screening in China due to the substantial
efforts of all levels of the government. Four large-scale population-based screening …

Ongoing controversy over the optimal approach to breast cancer screening has led to
discordant professional society recommendations, particularly in women age 40 to 49 years …

The application of artificial intelligence and machine learning (ML) technologies in
healthcare have immense potential to improve the care of patients. While there are some …

Breast cancer risk assessment can inform the use of screening and prevention modalities.
We investigated the performance of the Breast Cancer Surveillance Consortium (BCSC) risk …