Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome
stability by delaying cell division until accurate chromosome segregation can be …

Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …

The appropriate timing of events that lead to chromosome segregation during mitosis and
cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for
establishing mitotic chromosome condensation. The primary roles of TOP2A in mitosis have …

Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and
aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct …

Dividing cells almost always adopt a spherical shape. This is true of most eukaryotic cells
lacking a rigid cell wall and is observed in tissue culture and single-celled organisms, as …

A common assumption is that human chromosomes carry equal chances of mis-segregation
during compromised cell division. Human chromosomes vary in multiple parameters that …

Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell
division. Multipolar spindles are often seen in human cancers and are usually associated …