The microcirculation is responsible for orchestrating adjustments in vascular tone to match
local tissue perfusion with oxygen demand. Beyond this metabolic dilation, the …

Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by
cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in …

Local increase in blood flow during neural activity forms the basis for functional brain
imaging, but its mechanism remains poorly defined. Here we show that cortical astrocytes in …

Endothelial cells release several compounds, including prostacyclin, NO, and endothelium-
derived hyperpolarizing factor (EDHF), that mediate the vascular effects of vasoactive …

Arachidonic acid (AA) 1 is present in vivo esterified to cell membrane glycerophospholipids.
Activation of phospholipases (eg cytosolic phospholipase A2) releases free AA from the …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established
the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways …

Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …

Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine
mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by …

Members of the nuclear-receptor superfamily mediate crucial physiological functions by
regulating the synthesis of their target genes. Nuclear receptors are usually activated by …