Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
X Xu, Q Peng, X Jiang, S Tan, Y Yang… - … & Molecular Medicine, 2023 - nature.com
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …
Glycosylation: mechanisms, biological functions and clinical implications
M He, X Zhou, X Wang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …
during or after translation through the addition or removal of one or more functional groups …
Cell–cell communication inference and analysis in the tumour microenvironments from single-cell transcriptomics: data resources and computational strategies
Carcinomas are complex ecosystems composed of cancer, stromal and immune cells.
Communication between these cells and their microenvironments induces cancer …
Communication between these cells and their microenvironments induces cancer …
Targeting tumor glycans for cancer therapy: successes, limitations, and perspectives
N Berois, A Pittini, E Osinaga - Cancers, 2022 - mdpi.com
Simple Summary Aberrant glycosylation is a common feature of many cancers, and it plays
crucial roles in tumor development and biology. Cancer progression can be regulated by …
crucial roles in tumor development and biology. Cancer progression can be regulated by …
Role of glycosylation-related gene MGAT1 in pancreatic ductal adenocarcinoma
L Jiang, J Liu, S Zhang, C Jiang, J Huang… - Frontiers in …, 2024 - frontiersin.org
Background pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a very
poor prognosis and a complex tumor microenvironment, which plays a key role in tumor …
poor prognosis and a complex tumor microenvironment, which plays a key role in tumor …
[HTML][HTML] Aberrant protein glycosylation: Implications on diagnosis and Immunotherapy
Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …
[HTML][HTML] Roles of glycosylation at the cancer cell surface: opportunities for large scale glycoproteomics
Cell surface glycosylation has a variety of functions, and its dysregulation in cancer
contributes to impaired signaling, metastasis and the evasion of the immune responses …
contributes to impaired signaling, metastasis and the evasion of the immune responses …
Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
Abstract The IL6-GP130-STAT3 pathway facilitates lung cancer progression and resistance
to tyrosine kinase inhibitors. Although glycosylation alters the stability of GP130, its effect on …
to tyrosine kinase inhibitors. Although glycosylation alters the stability of GP130, its effect on …
Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
YH Liu, CM Hu, YS Hsu, WH Lee - Cell Death & Disease, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadliest
cancer worldwide. The primary reasons for this are the lack of early detection methods and …
cancer worldwide. The primary reasons for this are the lack of early detection methods and …