Recent advances in fluorescence-based microscopy techniques, such as single molecule
fluorescence, Förster resonance energy transfer (FRET), fluorescence intensity fluctuations …

Single-pass membrane receptors contain extracellular domains that respond to external
stimuli and transmit information to intracellular domains through a single transmembrane …

G protein-coupled receptors (GPCRs) are important drug targets that mediate various
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …

The ability to sense external stimuli and dynamically respond lies at the core of cellular
homeostasis. G protein-coupled receptors (GPCRs), the largest family of membrane proteins …

While the existence and functional role of class C G-protein-coupled receptors (GPCR)
dimers is well established, there is still a lack of consensus regarding class A and B GPCR …

Talin is a force-sensing multidomain protein and a major player in cellular
mechanotransduction. Here, we use single-molecule magnetic tweezers to investigate the …

Ligand bias is the ability of ligands to differentially activate certain receptor signaling
responses compared with others. It reflects differences in the responses of a receptor to …

Eph receptor tyrosine kinases play a key role in cell-cell communication. Lack of structural
information on the entire multi-domain intracellular region of any Eph receptor has hindered …

The human epidermal growth factor receptor (EGFR/ERBB1) is a receptor tyrosine kinase
(RTK) that forms activated oligomers in response to ligand. Much evidence indicates that …

Chronic pain affects 20% to 45% of the global population and is often associated with the
development of anxio‐depressive disorders. Treatment of this debilitating condition remains …