Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …

The regulatory role of actin cytoskeleton on mitochondrial function is a growing research
field, but the underlying molecular mechanisms remain poorly understood. Specific actin …

Background Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac
insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA …

Background Myocardial iron deficiency (MID) in heart failure (HF) remains largely
unexplored. We aim to establish defining criterion for MID, evaluate its pathophysiological …

Abstract Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important
intracellular signalling and vesicle trafficking events via the generation of 3 …

The prognosis and treatment outcomes of heart failure (HF) patients rely heavily on disease
etiology, yet the majority of underlying signaling mechanisms are complex and not fully …

Mammalian cells integrate different types of stimuli that govern their fate. These stimuli
encompass biochemical as well as biomechanical cues (shear, tensile, and compressive …

BACKGROUND: Cardiac hypertrophy and its associated remodeling are among the leading
causes of heart failure. Lysine crotonylation is a recently discovered posttranslational …

Numerous studies have assembled a complex picture, in which extracellular stimuli and
intracellular signaling pathways modulate the chondrocyte phenotype. Because many …

Angiotensin converting enzyme-I (ACE-I) is a key therapeutic target of the renin–angiotensin–
aldosterone system (RAAS), the central pathway of blood pressure regulation. Food-derived …