Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic lipid
accumulation, which can progress to nonalcoholic steatohepatitis (NASH). Histone …

The key role of mitochondria in oxidative metabolism and redox homeostasis explains the
link between mitochondrial dysfunction and the development of metabolic disorders …

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its
prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 …

Phosphatidylinositol (PI) is a minor phospholipid with a characteristic fatty acid profile; it is
highly enriched in stearic acid at the sn-1 position and arachidonic acid at the sn-2 position …

Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of
phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles …

Renal failure is a major health problem that is increasing worldwide. To improve clinical
outcomes, we need to understand the basic mechanisms of kidney disease. Aging is a risk …

Genomic instability is an underlying hallmark of cancer and is closely associated with
defects in DNA damage repair (DDR). Chromatin relaxation is a prerequisite for DDR, but …