Tumour heterogeneity and a long-standing paucity of effective therapies other than
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …

Tumour cells often display an active metabolic profile, leading to the intracellular
accumulation of reactive oxygen species. As a member of the peroxidase family …

Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors
(MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify …

Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is
molecularly not understood. This disconnect is particularly apparent in cancer entities such …

Importance The optimal maintenance strategy after induction chemotherapy with anti–
epidermal growth factor receptor antibody for patients withRASwild-type metastatic …

As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation
by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction …

The genetic mutations that contribute to the transformation of healthy cells into cancerous
cells have been the subject of extensive research. The molecular aberrations that lead to …

Background Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading
cause of cancer-related mortality among women. Our previous study revealed that high …

At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp).
Inhibitors targeting various effectors within the ERKp have been developed and explored for …

Investigating the human genome is vital for identifying risk factors and devising effective
therapies to combat genetic disorders and cancer. Despite the extensive knowledge of the" …