Liquid-liquid phase separation of TDP-43 and FUS in physiology and pathology of neurodegenerative diseases
Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …
membraneless organelles with essential cellular function. However, aberrant phase …
[HTML][HTML] SOD1, more than just an antioxidant
During cellular respiration, radicals, such as superoxide, are produced, and in a large
concentration, they may cause cell damage. To combat this threat, the cell employs the …
concentration, they may cause cell damage. To combat this threat, the cell employs the …
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer
Background: Tumor metastasis of colorectal cancer (CRC) is the main cause of death in
most patients and the major difficulty in comprehensive CRC treatment. Circular RNAs …
most patients and the major difficulty in comprehensive CRC treatment. Circular RNAs …
Nuclear import receptor inhibits phase separation of FUS through binding to multiple sites
Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular
condensates, cellular compartments that concentrate macromolecules without surrounding …
condensates, cellular compartments that concentrate macromolecules without surrounding …
RNA dysregulation in amyotrophic lateral sclerosis
Z Butti, SA Patten - Frontiers in genetics, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
and is characterized by the degeneration of upper and lower motor neurons. It has become …
and is characterized by the degeneration of upper and lower motor neurons. It has become …
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of …
neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of …
The role of FUS gene variants in neurodegenerative diseases
H Deng, K Gao, J Jankovic - Nature Reviews Neurology, 2014 - nature.com
The neurodegenerative diseases are a diverse group of disorders characterized by
progressive loss of specific groups of neurons. These diseases affect different populations …
progressive loss of specific groups of neurons. These diseases affect different populations …
The solution structure of FUS bound to RNA reveals a bipartite mode of RNA recognition with both sequence and shape specificity
Fused in sarcoma (FUS) is an RNA binding protein involved in regulating many aspects of
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …
The neurogenetics of alternative splicing
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …
Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding
RGG/RG domains are the second most common RNA binding domain in the human
genome, yet their RNA-binding properties remain poorly understood. Here, we report a …
genome, yet their RNA-binding properties remain poorly understood. Here, we report a …