Lipid nanoparticles (LNPs) have shown promise as delivery vehicles for therapeutic
oligonucleotides, including antisense oligos (ONs), siRNA, and microRNA mimics and …

Tumor therapeutic efficacy is determined, to a great extent, by the delivery efficiency of
therapeutic drugs to their final targets. The cell nucleus has been proven to be the main …

Nanotechnology has shown tremendous promise in target-specific delivery of drugs and
genes in the body. Although passive and active targeted-drug delivery has addressed a …

Abstract Lipid-based colloidal particles have been extensively studied as systemic gene
delivery carriers. The topic that we would like to emphasize is the formulation/assembly of …

Gene delivery using nonviral approaches has been extensively studied as a basic tool for
intracellular gene transfer and gene therapy. In the past, the primary focus has been on …

Cell-penetrating peptides (CPPs) including TAT peptide (TATp) have been successfully
used for intracellular delivery of a broad variety of cargoes including various nanoparticulate …

Liposomes represent a widely varied and malleable class of drug carriers generally
characterized by the presence of one or more amphiphile bilayers enclosing an interior …

Cell‐penetrating peptides (CPPs) including TAT peptide (TATp) have been successfully
used for intracellular delivery of a broad variety of cargos including various nanoparticulate …

Cascades of systemic and intracellular obstacles, including low stability in blood, little tumor
accumulation, weak tumor penetration, poor cellular uptake, inefficient endosomal escape …

This feature article describes the recent developments in the design of cationic lipids and
their applications in gene delivery. Various structure–activity investigations explaining the …