Glutamine: metabolism and immune function, supplementation and clinical translation

V Cruzat, M Macedo Rogero, K Noel Keane, R Curi… - Nutrients, 2018 - mdpi.com
Glutamine is the most abundant and versatile amino acid in the body. In health and disease,
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …

The roles of glutamine in the intestine and its implication in intestinal diseases

MH Kim, H Kim - International journal of molecular sciences, 2017 - mdpi.com
Glutamine, the most abundant free amino acid in the human body, is a major substrate
utilized by intestinal cells. The roles of glutamine in intestinal physiology and management …

Metabolic insight of neutrophils in health and disease

S Kumar, M Dikshit - Frontiers in immunology, 2019 - frontiersin.org
Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with
distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered …

Understanding the pathophysiological changes via untargeted metabolomics in COVID‐19 patients

HO Doğan, O Şenol, S Bolat, ŞN Yıldız… - Journal of medical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is an infectious respiratory disease caused
by a new strain of the coronavirus. There is limited data on the pathogenesis and the cellular …

The physiologic response and associated clinical benefits from provision of early enteral nutrition

SA McClave, DK Heyland - Nutrition in Clinical Practice, 2009 - Wiley Online Library
Provision of enteral nutrition (EN) to critically ill patients early upon admission to the
intensive care unit exerts a beneficial physiologic effect that downregulates systemic …

Ammonia regulates chicken tracheal cell necroptosis via the LncRNA-107053293/MiR-148a-3p/FAF1 axis

W Wang, Q Shi, S Wang, H Zhang, S Xu - Journal of Hazardous Materials, 2020 - Elsevier
Ammonia (NH 3) is a known harmful gas that causes injury to the respiratory system.
Ammonia also exists in haze, forming secondary organic aerosols. However, the specific …

Ammonia induces Treg/Th1 imbalance with triggered NF-κB pathway leading to chicken respiratory inflammation response

Q Shi, W Wang, M Chen, H Zhang, S Xu - Science of the total environment, 2019 - Elsevier
Ammonia (NH 3) is a severe air pollutant and a component of haze (PM2. 5). The respiratory
tract is the first route of exogenous ammonia's entry into the human and animal body. Many …

bacterial translocation in the critically ill–evidence and methods of prevention

M Gatt, BS Reddy, J MacFie - Alimentary pharmacology & …, 2007 - Wiley Online Library
Background Delayed sepsis, systemic inflammatory response syndrome (SIRS) and
multiorgan failure remain major causes of morbidity and mortality on intensive care units …

The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses

NJ Serkova, TJ Standiford… - American journal of …, 2011 - atsjournals.org
Metabolomics, a science of systems biology, is the global assessment of endogenous
metabolites within a biologic system and represents a “snapshot” reading of gene function …

A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis

A Karimi, F Naeini, VA Azar, M Hasanzadeh… - Phytomedicine, 2021 - Elsevier
Background Sepsis is a life-threatening condition caused by a dysregulated host response
to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological …