Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

Embryogenesis is directed by morphogens that induce differentiation within a defined tissue
geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) …

During pre‐implantation development, the mammalian zygote transforms into the blastocyst,
the structure that will implant the embryo in the maternal uterus. Consisting of a squamous …

Embryo development requires biochemical signalling to generate patterns of cell fates and
active mechanical forces to drive tissue shape changes. However, how these processes are …

The sha** of human embryos begins with compaction, during which cells come into close
contact,. Assisted reproductive technology studies indicate that human embryos fail …

Organoids derived from human stem cells are a promising approach for disease modeling,
regenerative medicine, and fundamental research. However, organoid variability and limited …

Tissues form during development through mechanical compaction of their extracellular
matrix (ECM) and shape morphing, processes that result in complex-shaped structures that …

Mechanical forces exerted on neural crest cells control their collective migration and
differentiation. This perspective discusses our current understanding of neural crest …

The direction in which a cell divides is set by the orientation of its mitotic spindle and is
important for determining cell fate, controlling tissue shape, and maintaining tissue …

Embryo development is a critical and fascinating stage in the life cycle of many organisms.
Despite decades of research, the earliest stages of mammalian embryogenesis are still …