Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Billions of hectares of natural ecosystems have been degraded through human actions. The
global community has agreed on targets to halt and reverse these declines, and the …

Proposed genetic approaches for reducing human malaria include population modification,
which introduces genes into vector mosquitoes to reduce or prevent parasite transmission …

With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is
no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are …

A functioning gene drive system could fundamentally change our strategies for the control of
vector-borne diseases by facilitating rapid dissemination of transgenes that prevent …

A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver
antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The …

CRISPR homing gene drives can convert heterozygous cells with one copy of the drive
allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism …

Plasmodium relies on numerous agonists during its journey through the mosquito vector,
and these agonists represent potent targets for transmission-blocking by either inhibiting or …

Gene drives are a promising means of malaria control with the potential to cause sustained
reductions in transmission. In real environments, however, their impacts will depend on local …

Gene drive technology offers the promise for a high-impact, cost-effective, and durable
method to control malaria transmission that would make a significant contribution to …