Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

Cellular adaptation to hypoxia is a hallmark of cancer, but the relative contribution of hypoxia-
inducible factors (HIFs) versus other oxygen sensors to tumorigenesis is unclear. We employ …

Background In genomics, we often assume that continuous data, such as gene expression,
follow a specific kind of distribution. However we rarely stop to question the validity of this …

Single-cell RNA-seq (scRNA-seq) technologies are broadly applied to dissect the cellular
heterogeneity and expression dynamics, providing unprecedented insights into single-cell …

Macrophages are abundant immune cells in the microenvironment of diffuse large B-cell
lymphoma (DLBCL). Macrophage estimation by immunohistochemistry shows varying …

Current survival analysis of cancers confronts two key issues. While comprehensive
perspectives provided by data from multiple modalities often promote the performance of …

Soft tissue sarcomas (STS) are considered non-immunogenic, although distinct entities
respond to anti-tumor agents targeting the tumor microenvironment. This study's aims were …

Abstract Acute Myeloid Leukemia (AML) is currently diagnosed based on morphological
assessment of myeloid cells' features, immunophenotypic characterization of specific cell …

Background Despite the recognized roles of Sialic acid-binding Ig-like lectins (SIGLECs) in
endocytosis and immune regulation across cancers, their molecular intricacies in colon …

Traditional techniques for discovering novel drugs are too slow for 21st challenges, from
precision oncology to emerging global pandemics. The COVID-19 Pandemic demonstrated …