Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating
them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant …

Peptides have positively impacted the pharmaceutical industry as drugs, biomarkers, or
diagnostic tools of high therapeutic value. However, only a handful have progressed to the …

Covering: up to June 2009LL-37 is a human host defence peptide that has a wide range of
biological functions, including antimicrobial and immunomodulatory properties. This review …

Short antimicrobial peptides (sAMPs) belong to a significant repertoire of antimicrobial
agents and are known to possess enhanced antimicrobial activity, higher stability and less …

Antimicrobial peptides (AMPs), important effector molecules of the innate immune system,
also provide templates for designing novel antibiotics. Protegrin, an especially potent AMP …

We have created a structure-selectivity database (AMPad) of frog-derived, helical
antimicrobial peptides (AMPs), in which the selectivity was determined as a therapeutic …

In the last few years, the number of bacteria with enhanced resistance to conventional
antibiotics has dramatically increased. Most of such bacteria belong to regular microbial …

With the increase in immunocompromised patients in the recent years, fungal infections
have emerged as new and serious threat in hospitals. This, and the insufficiency of current …

The current global crisis of antibiotic drug resistance is driving the search for novel treatment
approaches. Antimicrobial peptides (AMPs) are small molecular weight proteins with varying …

Background Partial atomic charges are a well-established concept, useful in understanding
and modeling the chemical behavior of molecules, from simple compounds, to large …