Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …

In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory
syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence …

Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive
peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling …

Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Acute ischemic stroke and traumatic brain injury are a major cause of mortality and
morbidity. Due to the paucity of therapies, there is a pressing clinical demand for new …

Glioblastoma multiforme (GBM) is the most common form of brain tumor and is very
aggressive. Rapid migration and invasion of glioblastoma cells are two typical features …

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 has been prominent around the world since it was first …

The central function of the immune system is to protect the host from environmental agents
such as microbes or chemicals, thereby preserving the integrity of the body, and preventing …

The kallikrein kinin system (KKS) consists of serine proteases involved in the production of
peptides called kinins, principally bradykinin and Lys-bradykinin (kallidin). The KKS …