Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA
receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or …

Retinoic acid (RA) signalling has a central role during vertebrate development. RA
synthesized in specific locations regulates transcription by interacting with nuclear RA …

Generation of homogeneous populations of subtype-specific cardiomyocytes (CMs) derived
from human induced pluripotent stem cells (iPSCs) and their comprehensive phenoty** is …

Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling
during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by …

Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in
areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium …

Retinoic acid (RA), the active form of vitamin A, is a small lipophilic molecule that acts as a
signalling molecule in vertebrates by binding to nuclear receptors (heterodimers of RA …

In this review, we focus on two important steps in the formation of the embryonic heart:(i) the
progressive addition of late differentiating progenitor cells from the second heart field that …

Retinoic acid (RA) is a morphogen derived from retinol (vitamin A) that plays important roles
in cell growth, differentiation, and organogenesis. The production of RA from retinol requires …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

The epicardium, the outer epithelial layer that covers the myocardium, derives from a
transient organ known as pro-epicardium, crucial during heart organogenesis. The pro …