The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Macroautophagy/autophagy, is widely recognized for its crucial role in enabling cell survival
and maintaining cellular energy homeostasis during starvation or energy stress. Its …

Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …

The major energy source for most cells is glucose, from which ATP is generated via
glycolysis and/or oxidative metabolism. Glucose deprivation activates AMP-activated protein …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

In healthy individuals, metabolically quiescent T cells survey lymph nodes and peripheral
tissues in search of cognate antigens. During infection, T cells that encounter cognate …

AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …

Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …