Interferon‐inducible transmembrane (IFITM) proteins are a family of small homologous
proteins, localized in the plasma and endolysosomal membranes, which confer cellular …

COPD affects millions of people and is now ranked as the third leading cause of death
worldwide. This largely untreatable chronic airway disease results in irreversible destruction …

Allergic asthma is characterized by goblet cell metaplasia and subsequent mucus
hypersecretion that contribute to the morbidity and mortality of this disease. Here, we explore …

Epithelial barrier tissues such as the skin and airway form an essential interface between the
mammalian host and its external environment. These physical barriers are crucial to prevent …

Asthma is the most prevalent chronic inflammatory disease of the airways in children. The
most prevalent phenotype of asthma is eosinophilic asthma, which is driven by a Th2 …

We have previously demonstrated that upregulation of Sonic hedgehog (SHH) expression in
allergic airway epithelia essentially contributes to the goblet cell metaplasia and mucous …

Abstract Heat shock protein 90 (HSP90) molecular chaperone is responsible for the
stabilization and biological activity of a diverse set of client proteins. We have previously …

Allergic asthma is a common inflammatory airway disease in which Th2 immune response
and inflammation are thought to be triggered by inhalation of environmental allergens. Many …

Background Circular RNAs (circRNAs) play potentially important roles in various human
diseases; however, their roles in the goblet cell metaplasia of asthma remain unknown …

Src homology domain 2–containing protein tyrosine phosphatase 2 (SHP2) participates in
multiple cell functions including cell shape, movement, and differentiation. Therefore, we …