The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

The nasal route has been used for many years for the local treatment of nasal diseases.
More recently, this route has been gaining momentum, due to the possibility of targeting the …

Chronic rhinosinusitis is a common disease worldwide, and the frequently prescribed nasal
sprays do not sufficiently deliver the topical medications to the target sites so that the final …

Abstract Evaluation of the regional intranasal delivery of locally acting drugs in children is
challenging. Anatomical nasal airway replicas potentially can provide a robust pre-clinical …

The transport and deposition (TD) of inhaled aerosol particles in airways of human lungs are
important for therapeutically targeted drug delivery in respiratory tracts. The airflow and …

Numerical simulations of the dispersion and deposition of poly-disperse particles in a patient-
specific human nasal configuration are performed. Computed tomography (CT) images are …

BACKGROUND: High-flow nasal cannula (HFNC) systems employ different methods to
provide aerosol to patients. This study compared delivery efficiency, particle size, and …

Background: The majority of current nasal delivery devices, commercialized for children, are
developed for adults. Differences in the dose reaching the target are expected due to …

In vitro nasal models can potentially facilitate development and approval of nasal drug
products. This study aims to evaluate the potential for using regional deposition …

The nasal olfactory region is a potential route for non-invasive delivery of drugs directly from
the nasal epithelium to the brain, bypassing the often impermeable blood-brain barrier …