Skeletal muscle is an essential tissue that attaches to bones and facilitates body
movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an …

Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …

Mechanotransduction is the physiological process where cells sense and respond to
mechanical loads. This paper reclaims the term “mechanotherapy” and presents the current …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Skeletal muscle is the largest organ of human body with several important roles in everyday
movement and metabolic homeostasis. The limited ability of small animal models of muscle …

Healthy skeletal muscle possesses the extraordinary ability to regenerate in response to
small‐scale injuries; however, this self‐repair capacity becomes overwhelmed with aging …

Skeletal myoblasts are an attractive cell type for transplantation because they are
autologous and resistant to ischemia. However, clinical trials of myoblast transplantation in …

Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a
wide range of signals such as motor input, exercise, and disease. Small animal models have …

Mechanical loading of skeletal muscle results in molecular and phenotypic adaptations
typified by enhanced muscle size. Studies on humans are limited by the need for repeated …

Mechanical signals are critical to the development and maintenance of skeletal muscle, but
the mechanisms that convert these shape changes to biochemical signals is not known …