Gold complexes in anticancer therapy: from new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Recent development of gold (I) and gold (III) complexes as therapeutic agents for cancer diseases

Y Lu, X Ma, X Chang, Z Liang, L Lv, M Shan… - Chemical Society …, 2022 - pubs.rsc.org
Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

Riding the metal wave: A review of the latest developments in metal-based anticancer agents

S Abdolmaleki, A Aliabadi, S Khaksar - Coordination Chemistry Reviews, 2024 - Elsevier
Metal-based complexes have demonstrated significant anticancer effects and have emerged
as candidates with great potential for cancer therapy. These agents are effective in a variety …

Recent advances in gold–NHC complexes with biological properties

M Mora, MC Gimeno, R Visbal - Chemical Society Reviews, 2019 - pubs.rsc.org
This tutorial review covers the recent advances made in the study of gold complexes
containing N-heterocyclic carbene ligands with biological properties. The great stability …

Preparation and Post-Assembly Modification of Metallosupramolecular Assemblies from Poly(N-Heterocyclic Carbene) Ligands

MM Gan, JQ Liu, L Zhang, YY Wang, FE Hahn… - Chemical …, 2018 - ACS Publications
Although the coordination chemistry of N-heterocyclic carbenes (NHCs) with transition
metals has been explored for half a century, only in the past ten years has the chemistry of …

Metal complex interactions with DNA

BJ Pages, DL Ang, EP Wright, JR Aldrich-Wright - Dalton transactions, 2015 - pubs.rsc.org
Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic
and genomic methods. The diversity of transition metal complexes is also growing, as the …

Organometallic anticancer compounds

G Gasser, I Ott, N Metzler-Nolte - Journal of medicinal chemistry, 2011 - ACS Publications
The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs

W Liu, R Gust - Chemical Society Reviews, 2013 - pubs.rsc.org
The discovery of cisplatin's antitumor activity in 1969 prompted the search for novel metal-
containing complexes as potential anticancer drugs. Among these novel complexes, metal N …

N-Heterocyclic carbene metal complexes in medicinal chemistry

L Oehninger, R Rubbiani, I Ott - Dalton Transactions, 2013 - pubs.rsc.org
Metal complexes with N-heterocyclic carbene (NHC) ligands are widely used in chemistry
due to their catalytic properties and applied for olefin metathesis among other reactions. The …

A promising future of metal‐N‐heterocyclic carbene complexes in medicinal chemistry: The emerging bioorganometallic antitumor agents

Q Zhao, B Han, C Peng, N Zhang… - Medicinal Research …, 2024 - Wiley Online Library
Metal complexes based on N‐heterocyclic carbene (NHC) ligands have emerged as
promising broad‐spectrum antitumor agents in bioorganometallic medicinal chemistry. In …