The landscape of mRNA nanomedicine

X Huang, N Kong, X Zhang, Y Cao, R Langer, W Tao - Nature Medicine, 2022 - nature.com
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …

mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Nanotechnology-based mRNA vaccines

S Chen, X Huang, Y Xue, E Álvarez-Benedicto… - Nature Reviews …, 2023 - nature.com
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …

Branched chemically modified poly (A) tails enhance the translation capacity of mRNA

H Chen, D Liu, J Guo, A Aditham, Y Zhou, J Tian… - Nature …, 2024 - nature.com
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a
general therapeutic modality is limited by its instability and low translation capacity. To …

The use of RNA-based treatments in the field of cancer immunotherapy

M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

Nanodelivery of nucleic acids

BB Mendes, J Conniot, A Avital, D Yao… - Nature reviews …, 2022 - nature.com
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

Chemically modified platforms for better RNA therapeutics

Y Shi, X Zhen, Y Zhang, Y Li, S Koo, Q Saiding… - Chemical …, 2024 - ACS Publications
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

[HTML][HTML] The storage and in-use stability of mRNA vaccines and therapeutics: not a cold case

EO Blenke, E Örnskov, C Schöneich, GA Nilsson… - Journal of …, 2023 - Elsevier
The remarkable impact of mRNA vaccines on mitigating disease and improving public
health has been amply demonstrated during the COVID-19 pandemic. Many new mRNA …

A 5′ UTR language model for decoding untranslated regions of mRNA and function predictions

Y Chu, D Yu, Y Li, K Huang, Y Shen, L Cong… - Nature Machine …, 2024 - nature.com
Abstract The 5′ untranslated region (UTR), a regulatory region at the beginning of a
messenger RNA (mRNA) molecule, plays a crucial role in regulating the translation process …

Tailor made: the art of therapeutic mRNA design

M Metkar, CS Pepin, MJ Moore - Nature Reviews Drug Discovery, 2024 - nature.com
Abstract mRNA medicine is a new and rapidly develo** field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …