Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

Alzheimer's disease (AD) is characterized by the selective vulnerability of specific neuronal
populations, the molecular signatures of which are largely unknown. To identify and …

We used a collection of 708 prospectively collected autopsied brains to assess the
methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that …

Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …

Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex
of Alzheimer's disease (AD) patients several decades ago. However, their role in AD …

Astrocytes are key active elements of the brain that contribute to information processing.
They not only provide neurons with metabolic and structural support, but also regulate …

Astrocytes perform a wide variety of essential functions defining normal operation of the
nervous system and are active contributors to the pathogenesis of neurodegenerative …

Since the original description of amyloid-β plaques and tau tangles more than 100 years
ago, these lesions have been considered the neuropathological hallmarks of Alzheimer …

Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's
disease (AD). Yet, not much is known about the molecular alterations underlying this …