The unraveling of the regulatory mechanisms that govern neuronal excitability is a major
challenge for neuroscientists worldwide. Neurotransmitters play a critical role in maintaining …

The dopamine D1 receptor (D1R) is a Gαs/olf-coupled GPCR that is expressed in the
midbrain and forebrain, regulating motor behavior, reward, motivational states, and cognitive …

Powerful associations that link drugs of abuse with cues in the drug-paired environment
often serve as prepotent relapse triggers. Drug-associated contexts and cues activate …

Hippocampal synaptic plasticity is widely considered the cellular basis of learning and
spatial memory processes. This article highlights the central role of Ca 2+ release from the …

Neuronal PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) is a protective transcriptional
regulator whose dysfunction has been linked to a variety of neuropsychiatric and metabolic …

Signaling from the synapse to nucleus is mediated by the integration and propagation of
both membrane potential changes (postsynaptic potentials) and intracellular second …

Neuronal alternative splicing is a key gene regulatory mechanism in the brain. However, the
spliceosome machinery is insufficient to fully specify splicing complexity. In considering the …

The expression of several hippocampal genes implicated in learning and memory
processes requires that Ca2+ signals generated in dendritic spines, dendrites, or the soma …

Structural plasticity of dendritic spines in the nucleus accumbens (NAc) is crucial for learning
from aversive experiences. Activation of NMDA receptors (NMDARs) stimulates Ca2+ …

Dysfunctional dopamine signaling is implicated in various neuropsychological disorders.
Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium …