One of the most important issues facing cartilage tissue engineering is the inability to move
technologies into the clinic. Despite the multitude of current research in the field, it is known …

Hyaline cartilage is the nonlinear, inhomogeneous, anisotropic, poro-viscoelastic connective
tissue that serves as friction-reducing and load-bearing cushion in synovial joints and is vital …

Bottom-up biofabrication approaches combining micro-tissue fabrication techniques with
extrusion-based 3D printing of thermoplastic polymer scaffolds are emerging strategies in …

Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of
the knee joint is important for diagnosing early disease and develo** new and effective …

Cartilage tissue engineering has primarily focused on the generation of grafts to repair
cartilage defects due to traumatic injury and disease. However engineered cartilage tissues …

Cell dedifferentiation is the process by which cells grow reversely from a partially or
terminally differentiated stage to a less differentiated stage within their own lineage. This …

This review explores scaffold-free methods as an additional paradigm for tissue
engineering. Musculoskeletal cartilages—for example articular cartilage, meniscus …

The dedifferentiation of chondrocytes in cartilage tissue engineering (CTE) remains an
unsolved challenge for the successful repair of severe articular cartilage defects. We …

Since material stiffness controls many cell functions, we reviewed the currently available
knowledge on stiffness sensing and elucidated what is known in the context of clinical and …

The process of cartilage destruction in the diarthrodial joint is progressive and irreversible.
This destruction is extremely difficult to manage and frustrates researchers, clinicians, and …