Purpose Selinexor is a novel XPO1 inhibitor which inhibits the export of tumor suppressor
proteins and oncoprotein mRNAs, leading to cell-cycle arrest and apoptosis in cancer cells …

Introduction: Despite unprecedented advances in the treatment of multiple myeloma (MM),
almost all patients develop a disease that is resistant to the five most commonly used and …

Background & Aims Long non-coding RNAs (lncRNAs) are expressed in tissue-specific
pattern, but it is not clear how these are regulated. We aimed to identify squamous cell …

Traditional drug screening models are often unable to faithfully recapitulate human
physiology in health and disease, motivating the development of microfluidic organs-on-a …

The nuclear export protein, exportin-1 (XPO1/CRM1), is overexpressed in many cancers and
correlates with poor prognosis. Selinexor, a first-in-class Selective Inhibitor of Nuclear Export …

Simple Summary Ewing sarcoma (EwS) is a highly aggressive and metastatic cancer in
children and adolescents. Canonical therapy mainly comprises the combination of intensive …

Soft tissue and bone sarcomas are malignancies of mesenchymal origin, and more than 50
subtypes are defined. For most sarcomas, locally advanced or unresectable disease is still …

Simple Summary Ewing sarcoma is a malignant pediatric bone cancer currently lacking
targeted therapy. In the US there are~ 200 patients diagnosed each year and relapse is …

Sarcomas represent a distinct group of rare malignant tumors with high heterogeneity.
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …

Purpose: Agents extracted from natural sources with antitumor property have attracted
considerable attention from researchers and clinicians because of their safety, efficacy, and …