Assembly of metagenomic sequence data into microbial genomes is of fundamental value to
improving our understanding of microbial ecology and metabolism by elucidating the …

Reference genomes are essential for analyzing the metabolic and functional potentials of
microbiomes. However, microbial genome resources are limited because most of …

Maximal growth rate is a basic parameter of microbial lifestyle that varies over several orders
of magnitude, with doubling times ranging from a matter of minutes to multiple days. Growth …

In each genome, synonymous codons are used with different frequencies; this general
phenomenon is known as codon usage bias. It has been previously recognised that codon …

Metagenomics provides a means of assessing the total genetic pool of all the microbes in a
particular environment, in a culture-independent manner. It has revealed unprecedented …

Most environments harbor large numbers of microbial taxa with ecologies that remain poorly
described and characterizing the functional capabilities of whole communities remains a key …

Elucidating the relative importance of species interactions and assembly mechanisms in
regulating bacterial community structure and functions, especially the abundant and rare …

Efficient nutrient usage is a trait under universal selection. A substantial part of cellular
resources is spent on making nucleotides. We thus expect preferential use of cheaper …

Whether codon usage fine-tunes mRNA translation in mammals remains controversial, with
recent papers suggesting that production of proteins in specific Gene Ontological (GO) …

Genetic manipulation is one of the central strategies that biologists use to investigate the
molecular underpinnings of life and its diversity. Thus, advances in genetic manipulation …