Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …
β− Arrestins: structure, function, physiology, and pharmacological perspectives
The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …
are multifunctional intracellular proteins that regulate the activity of a very large number of …
Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials
Background In the treatment of type 2 diabetes, GLP-1 receptor agonists lower blood
glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and …
glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and …
Targeting GLP-1 receptor trafficking to improve agonist efficacy
B Jones, T Buenaventura, N Kanda… - Nature …, 2018 - nature.com
Abstract Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion
from pancreatic beta cells, causes weight loss, and is an important pharmacological target in …
from pancreatic beta cells, causes weight loss, and is an important pharmacological target in …
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes
Abstract Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that
has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …
has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …
PDX1 is the cornerstone of pancreatic β-cell functions and identity
N Ebrahim, K Shakirova… - Frontiers in Molecular …, 2022 - frontiersin.org
Diabetes has been a worldwide healthcare problem for many years. Current methods of
treating diabetes are still largely directed at symptoms, aiming to control the manifestations …
treating diabetes are still largely directed at symptoms, aiming to control the manifestations …
GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function
N Zaïmia, J Obeid, A Varrault, J Sabatier, C Broca… - Cell reports, 2023 - cell.com
Summary Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic
polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose …
polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose …
A metabolic role for CD47 in pancreatic β cell insulin secretion and islet transplant outcomes
Diabetes is a global public health burden and is characterized clinically by relative or
absolute insulin deficiency. Therapeutic agents that stimulate insulin secretion and improve …
absolute insulin deficiency. Therapeutic agents that stimulate insulin secretion and improve …
[HTML][HTML] Intraislet glucagon signaling is critical for maintaining glucose homeostasis
Glucagon, a hormone released from pancreatic α cells, plays a key role in maintaining
proper glucose homeostasis and has been implicated in the pathophysiology of diabetes. In …
proper glucose homeostasis and has been implicated in the pathophysiology of diabetes. In …
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
BDNF signaling in hypothalamic circuitries regulates mammalian food intake. However,
whether BDNF exerts metabolic effects on peripheral organs is currently unknown. Here, we …
whether BDNF exerts metabolic effects on peripheral organs is currently unknown. Here, we …