Mitochondria are a source of reactive oxygen species (ROS). Mitochondrial diseases are the
result of inherited defects in mitochondrially expressed genes. One potential …

The thioredoxin family consists of a small group of redox proteins present in all organisms
and composed of thioredoxins (TRXs), glutaredoxins (GLRXs) and peroxiredoxins (PRDXs) …

Saccharomyces boulardii is the only probiotic yeast with US Food and Drug Administration
approval. It is routinely used to prevent or treat acute diarrhea and other gastrointestinal …

Friedreich's ataxia is the most common inherited autosomal recessive ataxia and is
characterized by progressive degeneration of the peripheral and central nervous systems …

Manipulating the apoptotic response of Candida albicans may help in the control of this
opportunistic pathogen. The metacaspase Mca1p has been described as a key protease for …

Mammalian apoptosis and yeast programmed cell death (PCD) share a variety of features
including reactive oxygen species production, protease activity and a major role played by …

Friedreich's ataxia (FRDA), the most common inherited ataxia in the Caucasian population,
is a multisystemic disease caused by a significant decrease in the frataxin level. To identify …

Recent reports suggest that the yeast Saccharomyces cerevisiae caspase‐related
metacaspase, Mca1, is required for cell‐autonomous cytoprotective functions that slow …

Caspase proteases are responsible for the regulated disassembly of the cell into apoptotic
bodies during mammalian apoptosis. Structural homologues of the caspase family (called …

Mancozeb (MZ), a mixture of ethylene-bis-dithiocarbamate manganese and zinc salts, is one
of the most widely used fungicides in agriculture. Toxicologic studies in mammals and …