1H-Detected Biomolecular NMR under Fast Magic-Angle Spinning
T Le Marchand, T Schubeis, M Bonaccorsi… - Chemical …, 2022 - ACS Publications
Since the first pioneering studies on small deuterated peptides dating more than 20 years
ago, 1H detection has evolved into the most efficient approach for investigation of …
ago, 1H detection has evolved into the most efficient approach for investigation of …
Deuteration for high-resolution detection of protons in protein magic angle spinning (MAS) solid-state NMR
B Reif - Chemical Reviews, 2021 - ACS Publications
Proton detection developed in the last 20 years as the method of choice to study
biomolecules in the solid state. In perdeuterated proteins, proton dipolar interactions are …
biomolecules in the solid state. In perdeuterated proteins, proton dipolar interactions are …
High and fast: NMR protein–proton side-chain assignments at 160 kHz and 1.2 GHz
M Callon, D Luder, AA Malär, T Wiegand, V Římal… - Chemical …, 2023 - pubs.rsc.org
The NMR spectra of side-chain protons in proteins provide important information, not only
about their structure and dynamics, but also about the mechanisms that regulate interactions …
about their structure and dynamics, but also about the mechanisms that regulate interactions …
Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications
N Altincekic, SM Korn, NS Qureshi… - Frontiers in molecular …, 2021 - frontiersin.org
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses
a severe threat to humanity and demands the redirection of scientific efforts and criteria to …
a severe threat to humanity and demands the redirection of scientific efforts and criteria to …
Pure isotropic proton solid state NMR
Resolution in proton solid state magic angle sample spinning (MAS) NMR is limited by the
intrinsically imperfect nature of coherent averaging induced by either MAS or multiple pulse …
intrinsically imperfect nature of coherent averaging induced by either MAS or multiple pulse …
Two‐dimensional Pure Isotropic Proton Solid State NMR
One key bottleneck of solid‐state NMR spectroscopy is that 1H NMR spectra of organic
solids are often very broad due to the presence of a strong network of dipolar couplings. We …
solids are often very broad due to the presence of a strong network of dipolar couplings. We …
Sub-stoichiometric Modulation of Viral Targets─ Potent Antiviral Agents That Exploit Target Vulnerability
NA Meanwell - ACS Medicinal Chemistry Letters, 2023 - ACS Publications
The modulation of oligomeric viral targets at sub-stoichiometric ratios of drug to target has
been advocated for its efficacy and potency, but there are only a limited number of …
been advocated for its efficacy and potency, but there are only a limited number of …
Analysis of the structure and interactions of the SARS-CoV-2 ORF7b accessory protein
SARS-CoV-2 carries a sizeable number of proteins that are accessory to replication but may
be essential for virus–host interactions and modulation of the host immune response. Here …
be essential for virus–host interactions and modulation of the host immune response. Here …
Divide and Conquer: A Tailored Solid‐state NMR Approach to Study Large Membrane Protein Complexes
SQ **ang, C Pinto, M Baldus - … Chemie International Edition, 2022 - Wiley Online Library
Membrane proteins are known to exert many essential biological functions by forming
complexes in cell membranes. An example refers to the β‐barrel assembly machinery …
complexes in cell membranes. An example refers to the β‐barrel assembly machinery …
Hepatitis Delta Antigen Retains the Assembly Domain as the Only Rigid Entity
Y Yang, ML Fogeron, AA Malär, L Lecoq… - Journal of the …, 2024 - ACS Publications
The hepatitis delta virus (HDV) S-HDAg and L-HDAg antigens are the two isoforms of the
single protein encoded by the viral genome. Together with the double-stranded RNA …
single protein encoded by the viral genome. Together with the double-stranded RNA …