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Nucleic acid drugs: recent progress and future perspectives
X Sun, S Setrerrahmane, C Li, J Hu, H Xu - Signal Transduction and …, 2024 - nature.com
High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area
of investigation for decades. Currently, most clinically approved therapeutics are small …
of investigation for decades. Currently, most clinically approved therapeutics are small …
Strategies and methods for improving the efficiency of CRISPR/Cas9 gene editing in plant molecular breeding
J Zhou, X Luan, Y Liu, L Wang, J Wang, S Yang, S Liu… - Plants, 2023 - mdpi.com
Following recent developments and refinement, CRISPR-Cas9 gene-editing technology has
become increasingly mature and is being widely used for crop improvement. The application …
become increasingly mature and is being widely used for crop improvement. The application …
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein
Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substania nigra (SN) and is associated with progressive …
loss of dopaminergic neurons in the substania nigra (SN) and is associated with progressive …
Advancements and prospects of CRISPR/Cas9 technologies for abiotic and biotic stresses in sugar beet
V Misra, AK Mall, H Pandey, S Srivastava… - Frontiers in …, 2023 - frontiersin.org
Sugar beet is a crop with high sucrose content, known for sugar production and recently
being considered as an emerging raw material for bioethanol production. This crop is also …
being considered as an emerging raw material for bioethanol production. This crop is also …
Comprehensive overview of bottom-up proteomics using mass spectrometry
Proteomics is the large scale study of protein structure and function from biological systems
through protein identification and quantification.“Shotgun proteomics” or “bottom-up …
through protein identification and quantification.“Shotgun proteomics” or “bottom-up …
The use of plant-derived exosome-like nanoparticles as a delivery system of CRISPR/Cas9-based therapeutics for editing long non-coding RNAs in cancer colon cells
T Hillman - Frontiers in Oncology, 2023 - frontiersin.org
Colon cancer is one of the leading causes of cancer in the United States. Colon cancer
develops from the many gene mutations found in the genomes of colon cancer cells. Long …
develops from the many gene mutations found in the genomes of colon cancer cells. Long …
[HTML][HTML] Advances in the Degradation of Polycyclic Aromatic Hydrocarbons by Yeasts: A Review
Polycyclic aromatic hydrocarbons (PAHs) are toxic organic compounds produced during the
incomplete combustion of organic materials and are commonly found in the environment …
incomplete combustion of organic materials and are commonly found in the environment …
Recent advances in genetic engineering to enhance plant-polysaccharide-degrading enzyme expression in Penicillium oxalicum: A brief review
Z Hu, Q Liu, B Ouyang, G Wang, C Wei… - International Journal of …, 2024 - Elsevier
With the depletion of non-renewable fossil fuels, there has been an increasing emphasis on
renewable biomass. Penicillium oxalicum is notable for its exceptional capacity to secrete a …
renewable biomass. Penicillium oxalicum is notable for its exceptional capacity to secrete a …
A comprehensive review of the advancement in omic technologies in the field of drug discovery and development
M Chauhan, S Kumar, A Biswas… - Letters in Drug …, 2024 - benthamdirect.com
Discovering new drugs is time-consuming and expensive and involves many different tools
from various domains. Numerous omic technologies, such as genomics, transcriptomics …
from various domains. Numerous omic technologies, such as genomics, transcriptomics …
CRISPR-Mediated In Situ Introduction or Integration of F9-Padua in Human iPSCs for Gene Therapy of Hemophilia B
Q Tang, Z Hu, J Zhao, T Zhou, S Tang, P Wang… - International Journal of …, 2023 - mdpi.com
Hemophilia B (HB) is an X-linked recessive disease caused by F9 gene mutation and
functional coagulation factor IX (FIX) deficiency. Patients suffer from chronic arthritis and …
functional coagulation factor IX (FIX) deficiency. Patients suffer from chronic arthritis and …