Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and
use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer …

Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has greatly improved
the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend …

Objective Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA
was detected in faeces of patients with COVID-19, the activity and infectivity of the virus in …

Brown adipose tissue (BAT) dissipates energy, and promotes cardiometabolic health. Loss
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …

The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

In the past decade, chimeric antigen receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach for combating cancers, demonstrating remarkable …

Immunotherapy harnesses the inherent immune system in the body to generate systemic
antitumor immunity, offering a promising modality for defending against cancer. However …

Checkpoint immunotherapies have been combined with other therapeutic modalities to
increase patient response rate and improve therapeutic outcome, which however …

Immunotherapy is revolutionizing the management of multiple solid tumors, and early data
have revealed the clinical activity of programmed cell death-1/programmed death ligand-1 …