[HTML][HTML] Kinetic models in industrial biotechnology–improving cell factory performance
An increasing number of industrial bioprocesses capitalize on living cells by using them as
cell factories that convert sugars into chemicals. These processes range from the production …
cell factories that convert sugars into chemicals. These processes range from the production …
Hog1: 20 years of discovery and impact
JL Brewster, MC Gustin - Science signaling, 2014 - science.org
The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being
revealed as a central signaling mediator during osmoregulation in the budding yeast …
revealed as a central signaling mediator during osmoregulation in the budding yeast …
Profile likelihood in systems biology
Inferring knowledge about biological processes by a mathematical description is a major
characteristic of Systems Biology. To understand and predict system's behavior the available …
characteristic of Systems Biology. To understand and predict system's behavior the available …
Spatial and temporal signal processing and decision making by MAPK pathways
Mitogen-activated protein kinase (MAPK) pathways are conserved from yeast to man and
regulate a variety of cellular processes, including proliferation and differentiation. Recent …
regulate a variety of cellular processes, including proliferation and differentiation. Recent …
Advancing metabolic models with kinetic information
Highlights•Kinetic models are crucial to understand complex dynamic processes.•Not all
model parameters need to be known precisely due to overlap** regulatory …
model parameters need to be known precisely due to overlap** regulatory …
Quantitative analysis of glycerol accumulation, glycolysis and growth under hyper osmotic stress
E Petelenz-Kurdziel, C Kuehn… - PLoS computational …, 2013 - journals.plos.org
We provide an integrated dynamic view on a eukaryotic osmolyte system, linking signaling
with regulation of gene expression, metabolic control and growth. Adaptation to osmotic …
with regulation of gene expression, metabolic control and growth. Adaptation to osmotic …
Constructing kinetic models of metabolism at genome‐scales: a review
S Srinivasan, WR Cluett, R Mahadevan - Biotechnology journal, 2015 - Wiley Online Library
Constraint‐based modeling of biological networks (metabolism, transcription and signal
transduction), although used successfully in many applications, suffer from specific …
transduction), although used successfully in many applications, suffer from specific …
Osmostress enhances activating phosphorylation of Hog1 MAP kinase by mono‐phosphorylated Pbs2 MAP 2K
Abstract The MAP kinase (MAPK) Hog1 is the central regulator of osmoadaptation in yeast.
When cells are exposed to high osmolarity, the functionally redundant Sho1 and Sln1 …
When cells are exposed to high osmolarity, the functionally redundant Sho1 and Sln1 …
Adaptive posttranslational control in cellular stress response pathways and its relationship to toxicity testing and safety assessment
Although transcriptional induction of stress genes constitutes a major cellular defense
program against a variety of stressors, posttranslational control directly regulating the …
program against a variety of stressors, posttranslational control directly regulating the …
Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans
C Komalapriya, D Kaloriti, AT Tillmann, Z Yin… - PLoS …, 2015 - journals.plos.org
The major fungal pathogen of humans, Candida albicans, mounts robust responses to
oxidative stress that are critical for its virulence. These responses counteract the reactive …
oxidative stress that are critical for its virulence. These responses counteract the reactive …