Mechanisms of long noncoding RNA function in development and disease

SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

[HTML][HTML] Glia–neuron interactions in the mammalian retina

E Vecino, FD Rodriguez, N Ruzafa, X Pereiro… - Progress in retinal and …, 2016 - Elsevier
The mammalian retina provides an excellent opportunity to study glia–neuron interactions
and the interactions of glia with blood vessels. Three main types of glial cells are found in …

[HTML][HTML] Single-cell RNA-seq analysis of retinal development identifies NFI factors as regulating mitotic exit and late-born cell specification

BS Clark, GL Stein-O'Brien, F Shiau, GH Cannon… - Neuron, 2019 - cell.com
Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

[HTML][HTML] lincRNAs: genomics, evolution, and mechanisms

I Ulitsky, DP Bartel - Cell, 2013 - cell.com
Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular …

Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

Y Lu, F Shiau, W Yi, S Lu, Q Wu, JD Pearson… - Developmental cell, 2020 - cell.com
The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …

Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution

JA Briggs, EJ Wolvetang, JS Mattick, JL Rinn, G Barry - Neuron, 2015 - cell.com
Only relatively recently has it become clear that mammalian genomes encode tens of
thousands of long non-coding RNAs (lncRNAs). A striking 40% of these are expressed …

Müller glial cell reprogramming and retina regeneration

D Goldman - Nature Reviews Neuroscience, 2014 - nature.com
Müller glia are the major glial component of the retina. They are one of the last retinal cell
types to be born during development, and they function to maintain retinal homeostasis and …

New functions of Müller cells

A Reichenbach, A Bringmann - Glia, 2013 - Wiley Online Library
Müller cells, the major type of glial cells in the retina, are responsible for the homeostatic and
metabolic support of retinal neurons. By mediating transcellular ion, water, and bicarbonate …

Long noncoding RNAs: functional surprises from the RNA world

JE Wilusz, H Sunwoo, DL Spector - Genes & development, 2009 - genesdev.cshlp.org
Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts that
includes tens of thousands of long noncoding RNAs with little or no protein-coding capacity …

P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression

EB Zhang, DD Yin, M Sun, R Kong, XH Liu… - Cell death & …, 2014 - nature.com
Recently, a novel class of transcripts, long non-coding RNAs (lncRNAs), is being identified
at a rapid pace. These RNAs have critical roles in diverse biological processes, including …