Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Parkinson's disease (PD) is a neurological movement disorder primarily resulting from
damage to the nigrostriatal dopaminergic pathway. To elucidate the pathogenesis …

Although there have been significant advances, pathogenesis in Parkinson's disease (PD) is
still poorly understood. Potential clues about pathogenesis that have not been systematically …

Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …

Amphetamine is a psychostimulant commonly used to treat several disorders, including
attention deficit, narcolepsy, and obesity. Plasmalemmal and vesicular monoamine …

Methamphetamine (METH) is an illicit psychostimulant that is widely abused in the world.
Several lines of evidence suggest that chronic METH abuse leads to neurodegenerative …

The basis for selective death of specific neuronal populations in neurodegenerative
diseases remains unclear. Parkinson's disease (PD) is a synucleinopathy characterized by a …

Autophagy is an evolutionarily ancient mechanism that ensures the lysosomal degradation
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …

Both reactive dopamine metabolites and mitochondrial dysfunction have been implicated in
the neurodegeneration of Parkinson's disease. Dopamine metabolites, dopamine quinone …

Whether amphetamine acts principally at the plasma membrane or at synaptic vesicles is
controversial. We find that d-amphetamine injection into the Planorbis giant dopamine …