The three RAS genes—HRAS, NRAS and KRAS—are collectively mutated in one-third of
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …

Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol …

The toxic properties of various nitrosamines in animals and humans are well established.
The parenteral or oral administration of the smallest quantities of diethylnitrosamine (DEN) …

Background Hepatocellular carcinoma (HCC) is still a major health problem, often
diagnosed at an advanced stage. The multikinase inhibitor sorafenib is to date the sole …

Every year almost 500,000 new patients are diagnosed with hepatocellular carcinoma
(HCC), a primary malignancy of the liver that is associated with a poor prognosis. Numerous …

Although inappropriate activation of the Wnt/β-catenin pathway has been implicated in the
development of hepatocellular carcinoma (HCC), the role of this signaling in liver …

We have established previously a mouse strain containing a mutant β-catenin allele of
which exon 3 was sandwiched by loxP sequences [Catnb lox (ex3)]. In this mouse strain, a …

Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

Ascorbate (vitamin C in primates) functions as a cofactor for a number of enzymatic reactions
represented by prolyl hydroxylases and as an antioxidant due to its ability to donate …

Tumor promoters are non-mutagenic chemicals which increase the probability of cancer by
accelerating the clonal expansion of cells transformed during tumor initiation. Phenobarbital …