Implantable antimicrobial biomaterials for local drug delivery in bone infection models

JD Caplin, AJ García - Acta biomaterialia, 2019 - Elsevier
Increased use of implantable biomedical devices demonstrates their potential in treating a
wide variety of ailments and disorders in bone trauma and orthopaedic, reconstructive, and …

Prevention of infection in open fractures: where are the pendulums now?

M Rupp, D Popp, V Alt - Injury, 2020 - Elsevier
Soft tissue management and fracture fixation including initial external fixation in Gustilo-
Anderson type II and type III open fractures are cornerstones in the treatment but details on …

Type III open tibia fractures: immediate antibiotic prophylaxis minimizes infection

WD Lack, MA Karunakar, MR Angerame… - … of orthopaedic trauma, 2015 - journals.lww.com
Objective: To examine the association between antibiotic timing and deep infection of type III
open tibia fractures. Design: Retrospective prognostic study. Setting: Level 1 Trauma Center …

A systematic review of animal models for Staphylococcus aureus osteomyelitis

W Reizner, JG Hunter, NT O'Malley… - European cells & …, 2014 - pmc.ncbi.nlm.nih.gov
Staphylococcus aureus (S. aureus) osteomyelitis is a significant complication for
orthopaedic patients undergoing surgery, particularly with fracture fixation and arthroplasty …

Prevention of infection in open fractures

CG Zalavras - Infectious Disease Clinics, 2017 - id.theclinics.com
Open fractures are often the result of high-energy trauma and may be associated with life-
threatening injuries. 1 Open fractures are characterized by definition by soft tissue injury that …

Therapeutics and delivery vehicles for local treatment of osteomyelitis

LH Cobb, EM McCabe, LB Priddy - Journal of Orthopaedic …, 2020 - Wiley Online Library
Osteomyelitis, or the infection of the bone, presents a major complication in orthopedics and
may lead to prolonged hospital visits, implant failure, and in more extreme cases …

Musculoskeletal infection in orthopaedic trauma: assessment of the 2018 international consensus meeting on musculoskeletal infection

WT Obremskey, WJ Metsemakers, DR Schlatterer… - JBJS, 2020 - journals.lww.com
Fracture-related infections (FRIs) are among the most common complications following
fracture fixation, and they have a huge economic and functional impact on patients. Because …

Antibiotic prophylaxis in orthopaedic surgery: difficult decisions in an era of evolving antibiotic resistance

DJ Bryson, DLJ Morris, FS Shivji… - The bone & joint …, 2016 - boneandjoint.org.uk
Prophylactic antibiotics can decrease the risk of wound infection and have been routinely
employed in orthopaedic surgery for decades. Despite their widespread use, questions still …

Fracture-related infection: current methods for prevention and treatment

AL Foster, TF Moriarty, A Trampuz… - Expert review of anti …, 2020 - Taylor & Francis
Introduction: Fracture-related infection (FRI) is a serious complication related to orthopedic
trauma, both from an infectious disease and a surgical point of view. The lack of scientific …

Infection after fracture osteosynthesis–part I: pathogenesis, diagnosis and classification

C Fang, TM Wong, TW Lau, KKW To… - Journal of …, 2017 - journals.sagepub.com
Bone and surgical site infections after osteosynthesis are notoriously difficult to manage and
pose a tremendous burden in fracture management. In this article, we use the term …