Chromosomics: Bridging the gap between genomes and chromosomes

JE Deakin, S Potter, R O'Neill, A Ruiz-Herrera… - Genes, 2019 - mdpi.com
The recent advances in DNA sequencing technology are enabling a rapid increase in the
number of genomes being sequenced. However, many fundamental questions in genome …

Evolution of 3D Chromatin Folding

L Álvarez-González… - Annual Review of Animal …, 2024 - annualreviews.org
Studies examining the evolution of genomes have focused mainly on sequence
conservation. However, the inner working of a cell implies tightly regulated crosstalk …

3D chromatin remodelling in the germ line modulates genome evolutionary plasticity

L Álvarez-González, F Burden, D Doddamani… - Nature …, 2022 - nature.com
Chromosome folding has profound impacts on gene regulation, whose evolutionary
consequences are far from being understood. Here we explore the relationship between 3D …

[HTML][HTML] Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals

L Álvarez-González, C Arias-Sardá, L Montes-Espuña… - Cell reports, 2022 - cell.com
Studying the similarities and differences in genomic interactions between species provides
fertile grounds for determining the evolutionary dynamics underpinning genome function …

Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes

D Thybert, M Roller, FCP Navarro, I Fiddes… - Genome …, 2018 - genome.cshlp.org
Understanding the mechanisms driving lineage-specific evolution in both primates and
rodents has been hindered by the lack of sister clades with a similar phylogenetic structure …

Chromosomal speciation in the genomics era: disentangling phylogenetic evolution of rock-wallabies

S Potter, JG Bragg, MPK Blom, JE Deakin… - Frontiers in …, 2017 - frontiersin.org
The association of chromosome rearrangements (CRs) with speciation is well established,
and there is a long history of theory and evidence relating to “chromosomal speciation.” …

[PDF][PDF] Large-Scale Chromosomal Changes Lead to Genome-Level Expression Alterations, Environmental Adaptation, and Speciation in the Gayal (Bos frontalis)

Y Li, S Wang, Z Zhang, J Luo, GL Lin… - Molecular Biology …, 2023 - academic.oup.com
Determining the functional consequences of karyotypic changes is invariably challenging
because evolution tends to obscure many of its own footprints, such as accumulated …

Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs

RE O'Connor, MN Romanov, LG Kiazim… - Nature …, 2018 - nature.com
Genomic organisation of extinct lineages can be inferred from extant chromosome-level
genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to …

Long noncoding RNAs in ubiquitination, protein degradation, and human diseases

P Guha, A Chini, A Rishi, SS Mandal - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Protein stability and turnover is critical in normal cellular and physiological process and their
misregulation may contribute to accumulation of unwanted proteins causing cellular …

A bird's-eye view of chromosomic evolution in the class Aves

RE O'Connor, R Kretschmer, MN Romanov, DK Griffin - Cells, 2024 - mdpi.com
Birds (Aves) are the most speciose of terrestrial vertebrates, displaying Class-specific
characteristics yet incredible external phenotypic diversity. Critical to agriculture and as …