Cerebrovascular disease (CVD) and Alzheimer's disease (AD) have more in common than
their association with ageing. They share risk factors and overlap neuropathologically. Most …

Microglia can transform into proinflammatory/classically activated (M1) or anti-inflammatory/
alternatively activated (M2) phenotypes following environmental signals related to …

Objective To investigate whether angiotensin receptor blockers protect against Alzheimer's
disease and dementia or reduce the progression of both diseases. Design Prospective …

Dopamine (DA) is one of the major neurotransmitters and participates in a number of
functions such as motor coordination, emotions, memory, reward mechanism …

Background Memory and cognitive impairments/disorders are the main clinical symptoms of
neurodegenerative diseases. The prevalence of such chronic conditions has increased over …

In Alzheimer's disease (AD) Aβ accumulates because of imbalance between the production
of Aβ and its removal from the brain. There is increasing evidence that in most sporadic …

With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Neurovascular coupling, or functional hyperaemia, refers to complex mechanisms of
communication between neurons, astrocytes and cerebral vessels which form the …

Arterial hypertension and stroke are strong independent risk factors for the development of
cognitive impairment and dementia. Persistently elevated blood pressure (BP) is known to …

There is wide recognition of a complex association between midlife hypertension and
cardiovascular disease and later development of Alzheimer's disease (AD) and cognitive …