Advances and opportunities in malaria population genomics

DE Neafsey, AR Taylor, BL MacInnis - Nature Reviews Genetics, 2021 - nature.com
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Measurably recombining malaria parasites

F Camponovo, CO Buckee, AR Taylor - Trends in parasitology, 2023 - cell.com
Genomic epidemiology has guided research and policy for various viral pathogens and
there has been a parallel effort towards using genomic epidemiology to combat diseases …

Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum

B Guo, V Borda, R Laboulaye, MD Spring… - Nature …, 2024 - nature.com
Malaria genomic surveillance often estimates parasite genetic relatedness using metrics
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …

Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana

M Vanhove, P Schwabl, C Clementson, AM Early… - PLoS …, 2024 - journals.plos.org
Plasmodium parasites, the causal agents of malaria, are eukaryotic organisms that
obligately undergo sexual recombination within mosquitoes. In low transmission settings …

Whole-genome surveillance identifies markers of Plasmodium falciparum drug resistance and novel genomic regions under selection in Mozambique

E Coonahan, H Gage, D Chen, EV Noormahomed… - MBio, 2023 - journals.asm.org
The emergence of Plasmodium falciparum drug resistance threatens the efficacy of
antimalarial therapies globally. Population genomic studies have been instrumental in …

Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis

M Carrasquilla, AM Early, AR Taylor… - PLoS …, 2022 - journals.plos.org
The human malaria parasite Plasmodium falciparum is globally widespread, but its
prevalence varies significantly between and even within countries. Most population genetic …

Fitness Costs of pfhrp2 and pfhrp3 Deletions Underlying Diagnostic Evasion in Malaria Parasites

S Nair, X Li, SC Nkhoma… - The Journal of Infectious …, 2022 - academic.oup.com
Background Rapid diagnostic tests based on detection of histidine-rich proteins (HRPs) are
widely used for malaria diagnosis, but parasites carrying pfhrp deletions can evade …

The changing epidemiology of Plasmodium vivax: Insights from conventional and novel surveillance tools

S Auburn, Q Cheng, J Marfurt, RN Price - PLoS medicine, 2021 - journals.plos.org
The changing epidemiology of Plasmodium vivax: Insights from conventional and novel
surveillance tools | PLOS Medicine Skip to main content Advertisement PLOS Medicine …

Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia

AM Kebede, E Sutanto, H Trimarsanto… - Scientific Reports, 2023 - nature.com
Ethiopia has the greatest burden of Plasmodium vivax in Africa, but little is known about the
epidemiological landscape of parasites across the country. We analysed the genomic …

Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas

E Sutanto, Z Pava, DF Echeverry, TM Lopera-Mesa… - Scientific Reports, 2023 - nature.com
Colombia aims to eliminate malaria by 2030 but remains one of the highest burden
countries in the Americas. Plasmodium vivax contributes half of all malaria cases, with its …