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Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Measurably recombining malaria parasites
F Camponovo, CO Buckee, AR Taylor - Trends in parasitology, 2023 - cell.com
Genomic epidemiology has guided research and policy for various viral pathogens and
there has been a parallel effort towards using genomic epidemiology to combat diseases …
there has been a parallel effort towards using genomic epidemiology to combat diseases …
Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum
Malaria genomic surveillance often estimates parasite genetic relatedness using metrics
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …
Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana
Plasmodium parasites, the causal agents of malaria, are eukaryotic organisms that
obligately undergo sexual recombination within mosquitoes. In low transmission settings …
obligately undergo sexual recombination within mosquitoes. In low transmission settings …
Whole-genome surveillance identifies markers of Plasmodium falciparum drug resistance and novel genomic regions under selection in Mozambique
E Coonahan, H Gage, D Chen, EV Noormahomed… - MBio, 2023 - journals.asm.org
The emergence of Plasmodium falciparum drug resistance threatens the efficacy of
antimalarial therapies globally. Population genomic studies have been instrumental in …
antimalarial therapies globally. Population genomic studies have been instrumental in …
Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis
The human malaria parasite Plasmodium falciparum is globally widespread, but its
prevalence varies significantly between and even within countries. Most population genetic …
prevalence varies significantly between and even within countries. Most population genetic …
Fitness Costs of pfhrp2 and pfhrp3 Deletions Underlying Diagnostic Evasion in Malaria Parasites
S Nair, X Li, SC Nkhoma… - The Journal of Infectious …, 2022 - academic.oup.com
Background Rapid diagnostic tests based on detection of histidine-rich proteins (HRPs) are
widely used for malaria diagnosis, but parasites carrying pfhrp deletions can evade …
widely used for malaria diagnosis, but parasites carrying pfhrp deletions can evade …
The changing epidemiology of Plasmodium vivax: Insights from conventional and novel surveillance tools
The changing epidemiology of Plasmodium vivax: Insights from conventional and novel
surveillance tools | PLOS Medicine Skip to main content Advertisement PLOS Medicine …
surveillance tools | PLOS Medicine Skip to main content Advertisement PLOS Medicine …
Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia
Ethiopia has the greatest burden of Plasmodium vivax in Africa, but little is known about the
epidemiological landscape of parasites across the country. We analysed the genomic …
epidemiological landscape of parasites across the country. We analysed the genomic …
Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas
Colombia aims to eliminate malaria by 2030 but remains one of the highest burden
countries in the Americas. Plasmodium vivax contributes half of all malaria cases, with its …
countries in the Americas. Plasmodium vivax contributes half of all malaria cases, with its …