This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

Prolonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly
understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan …

The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …

The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

With the goal of representing common denominators of aging in different organisms López-
Otín et al. in 2013 described nine hallmarks of aging. Since then, this representation has …

Aging is characterized by a deterioration in the maintenance of homeostatic processes over
time, leading to functional decline and increased risk for disease and death. The aging …

The life span of C. elegans can be increased via reduced function of the mitochondria;
however, the extent to which mitochondrial alteration in a single, distinct tissue may …

Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …

Destruction of habitat is the major cause for loss of biodiversity including variation in life
history and habitat ecology. Each species and population adapts to its environment …