Cellular and molecular mechanisms of chronic obstructive pulmonary disease

PJ Barnes - Clinics in chest medicine, 2014 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute …

Systemic manifestations and comorbidities of COPD

PJ Barnes, BR Celli - European respiratory journal, 2009 - publications.ersnet.org
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a
complex disease involving more than airflow obstruction. Airflow obstruction has profound …

Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study

B Waschki, A Kirsten, O Holz, KC Müller, T Meyer… - Chest, 2011 - Elsevier
Background Systemic effects of COPD are incompletely reflected by established prognostic
assessments. We determined the prognostic value of objectively measured physical activity …

Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease

BR Celli, N Locantore, J Yates… - American journal of …, 2012 - atsjournals.org
Rationale: Accurate prediction of mortality helps select patients for interventions aimed at
improving outcome. Objectives: Because chronic obstructive pulmonary disease is …

COPD-OSA overlap syndrome: evolving evidence regarding epidemiology, clinical consequences, and management

WT McNicholas - Chest, 2017 - Elsevier
COPD and OSA are both highly prevalent, which implies that both disorders occurring
together (overlap syndrome) is likely to be common based on chance association alone …

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

V Austin, PJ Crack, S Bozinovski, AA Miller… - Clinical …, 2016 - portlandpress.com
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and loss of lung function, and is currently the third largest cause of death in the …

Systemic inflammation and comorbidity in COPD: a result of 'overspill'of inflammatory mediators from the lungs? Review of the evidence

NJ Sinden, RA Stockley - Thorax, 2010 - thorax.bmj.com
Chronic obstructive pulmonary disease (COPD) is characterised by an inflammatory
response by the lungs to inhaled substances such as cigarette smoking and air pollutants. In …

Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index

MA Puhan, J Garcia-Aymerich, M Frey, G ter Riet… - The Lancet, 2009 - thelancet.com
Background The BODE index (including body-mass index, airflow obstruction, dyspnoea,
and exercise capacity) was an important contribution to the prognostic assessment of …

Body mass index and mortality in chronic obstructive pulmonary disease: a meta-analysis

C Cao, R Wang, J Wang, H Bunjhoo, Y Xu, W **ong - 2012 - journals.plos.org
Background The association between body mass index (BMI) and mortality in patients
suffering from chronic obstructive pulmonary disease (COPD) has been a subject of interest …

Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis

JM Fermont, KL Masconi, MT Jensen, R Ferrari… - Thorax, 2019 - thorax.bmj.com
Background Conventional measures to evaluate COPD may fail to capture systemic
problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying …